The pioneering golden age actress began her career in the silent film era and was featured in over 60 movies and will appear on quarters.
The coin, which will start to ship on 24 October, will have a close-up of Wong's head resting on her hand.
She's also donning her signature blunt flapper-era bangs, and in an ode to her showbiz legacy, the coin is framed by dots representing marquee lights.
"Along with the hard work, determination, and skill Anna May Wong brought to the profession of acting, I think it was her face and expressive gestures that really captivated movie audiences, so I included these elements next to her name," said Emily Damstra, the designer of the coin for the US Mint.
Wong was born Wong Liu Tsong in 1905 in Los Angeles. She made her film debut as an extra aged 14 in 1919's The Red Lantern. And in 1922, she got her breakthrough role in the silent drama The Toll of the Sea.
During her career, Wong hit out against biases in Hollywood that limited Asian American actors to stereotypical roles.
In the Times, it was said that she was angered by the laws at the time that banned people from different races from kissing onscreen.
Wong left the US in 1928 to seek better roles in Europe, where she had greater success, The Los Angeles Times reported.