But in between the main cast, some major celebrities made appearances as minor or background characters.
Here's a list of all the celebrity cameos made in the film.
Yo-Yo Ma as Birdie Jay's partygoer
The world-renowned cellist appeared as himself attending Birdie Jay's (Kate Hudson) pandemic party.
He lends a hand in helping figure out which classic song is coming from a mysterious box.
Natasha Lyonne, Kareem Abdul-Jabbar, Stephen Sondheim, and Angela Lansbury as Blanc's friends
In a very 2020 fashion, Blanc plays the game Among Us with his friends which just so happens to be actor Natasha Lyonne, former basketball player Kareem Abdul-Jabbar, composer Stephen Sondheim, and actor-singer Angela Lansbury.
Ethan Hawke as Efficient Man
Before the group of friends depart for Miles Bron's private island, they're greeted by his assistant, only known as "Efficient Man" in the credits.
Hawke appears just for a short bit where he sprays each person with some sort of disinfectant.
Hugh Grant as Phillip
Toward the end of the film, romantic comedy staple actor Hugh Grant appeared as Blanc's husband Phillip.
The movie teases Blanc's sexuality without directly stating anything pertaining to it, until Grant answers the door, covered in bread flour, on behalf of his husband.
Serena Williams as an on-call fitness instructor
The tennis star appeared as a virtual fitness instructor for Miles Bron.
Joseph Gordon-Levitt as the Hourly Dong
Although the actor doesn't make a physical appearance, he does voice the mystifying clock that 'dongs' every hour to keep the island on schedule.
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