It starts with his eyes. The camera pans in so closely you can see his veins, and the shape of his pores. It takes a few seconds before you realise he's not real.
This video is actually an incredibly realistic animation by Australian designer Chris Jones.
Mr Jones's freakishly detailed digital rendering of the human head (which he calls Mr Head, or Mr Ed for short) is also also joined by a hand in the video. You can read more about Mr Jones's efforts to build human body parts digitally, like some kind of modern day Frankenstein, here.