The role earned him nominations for two PrimeTime Emmy Awards and three Golden Globes, and launched him into cinematic stardom.
But rather than be impressed by his skills as an actor, Human Rights barrister Amal has been struck by his ER character’s endless dalliances.
"This has been a very, very disastrous thing for me because I forgot all of the terrible things I’d done as Dr. Ross," George admitted during a televised reunion with his fellow former cast members.
"My wife keeps going, ‘Is that it? Are you done? Season 3 -- do you finally settle down with Nurse Hathaway?
“It’s been a disaster for my marriage."
We’re not too worried about the state of the loved-up pair’s marriage
His comments were met with roars of laughter from his old co-stars, which included Julianna Marguiles, Anthony Edwards, Noah Wyle and Gloria Reuben.
The reunion was hosted by the Stars in the House series, which was launched last year to raise money for those worst hit by the Covid pandemic.
George added seeing his wife rewatch the show had left him with a greater appreciation for what he and his colleagues had achieved more than 25 years ago.
"I have to say, you know, it’s such great television," he said proudly.
The old friends laughed together during their Stars in the House reunion
Even so, fans should not get their hopes up: there’s no sign of a reboot on the cards.
"I don’t think you could do it at the level we did it," the 59-year-old said.
Marguile agreed, adding: "I don’t think you can reboot it. I think it’s what George said – you can’t capture lightning in a bottle twice. I think you have to leave what was so beautiful and move on. It feels like it would cheapen it for me."
But Ming-Na Wen, who played Jing-Mei Chen on the series, revealed that she wouldn’t be opposed to the idea.
“I would love to do a reboot only to be able to hang out with this group of people," she said.